Paroxetine is a chemical compound that works as an antidepressant belonging to a group of drugs called selective serotonin reuptake inhibitors(SSRIs). It is a benzodioxole, that consists of piperidine bearing 1,3-benzodioxol-5-yloxymethyl and 4-fluorophenyl substituents at positions 3, 4.

Structure & Formula

Paroxetine has the IUPAC name (3S, 4R)-3-(1,3-benzodioxol-5-yloxymethyl)-4-(4-fluorophenyl)piperidine and it has chemical formula as C19H2OFNO3.

The 2D structure of paroxetine is shown below.

Structure of Paroxetine
Structure of Paroxetine (Source)

Chemical & Physical Properties

The following are the chemical and physical properties of paroxetine.

Molecular Weight329.4
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count5
Rotatable Bond Count4
Exact Mass of the compound329.14272166
Topological Polar Surface Area39.7 Å2
Heavy Atom Count24
Formal Charge0
Isotope Atom Count0
Is it Canonicaliized?Yes
Defined Atom Stereocenter Count2
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
Physical appearanceSolid
Boiling Point451.7 ± 45.0℃
Melting Point120-138℃
Solubility5.4 mg/mL
Vapor Pressure4.79 × 10-8 mm Hg at 25℃


Paroxetine uses can be found in several situation in our lives, some of the uses are discussed below.

  • The chemical compound finds major applications in the treatment of canine and feline behavioral disorders.
  • The compound is used to treat depression, panic disorder, obsessive-compulsive disorder, anxiety disorders.
  • It is also used to treat post-traumatic stress disorder, and premenstrual dysphoric disorder.
  • It helps improve a person’s mood, sleep, appetite, energy levels, and also restore interest in daily living.


Following are the hazards of the compound

  • The compound is harmful if swallowed in higher dosages
  • It may damage fertility or unborn child.
  • Paroxetine has been found to be very toxic to aquatic life.
  • It may cause skin & eye irritation, and respiratory issues.

Side Effects

Some of the paroxetine side effects as medicine are:

  • Sickness (feeling weak or tired)
  • Nausea
  • Headaches
  • Diarrhea
  • Restlessness
  • Chest pains
  • Blurred vision
  • Unexpected weight gain or loss
  • Allergic reactions


How is Paroxetine stored?

The chemical compound is stored in a tightly closed container in a dry and well-ventilated environment, with tablets stored at a temperature between 15-30℃ and suspension at or below temperatures 25℃.

What are the most common side-effects of paroxetine?

Some of the most common side effects are nausea, drowsiness, loss of appetite, blurred vision, headaches, etc.

Can paroxetine make a person feel sleepy?

Yes, it may make a person feel sleepy.

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